Tag Archives: elderly

Why I hope to live until I die

Seventy-five years is all I want to live. I want to celebrate my life while I am still in my prime. My daughters and dear friends will continue to try to convince me that I am wrong and can live a valuable life much longer. And I retain the right to change my mind and offer a vigorous and reasoned defense of living as long as possible. That, after all, would mean still being creative after 75.

So wrote Ezekiel J. Emanuel, director of the Clinical Bioethics Department at the U.S. National Institutes of Health and head of the Department of Medical Ethics & Health Policy at the University of Pennsylvania, in the Atlantic magazine of September 17, 2014.

He argues that:

  1. He will have lived a complete life by then.
  2. Increased life expectancy has been accompanied by increased disease, accompanied by physical and mental disability.
  3. If we change our goals to match our ages, we still burden our children and alter their memories of us as decrepit rather than vibrant.
  4. “But 75 defines a clear point in time: for me, 2032. It removes the fuzziness of trying to live as long as possible.”

He concludes that certain medical tests and interventions that the larger population would consider quite normal should be ruled out after age 65, after age 70, after age 75.

It is a thoughtful and provocative essay that has attracted a lot of attention, presumably to the satisfaction of publisher and author. It could be that he wished to attract an audience, or it could be that as a bioethicist, he wished to begin a national conversation about end-of-life issues, rather than to be taken at face value. I would not question the sincerity of Dr. Emmanuel, nor would I question his education, which surpasses my own. I question his wisdom.

First, his choice of 75 is by his own admission arbitrary. Why not 74 or 76? Why not 79 or 81? Choosing an arbitrary age, or arbitrary criterion for anything, is a logical one-size-fits all or Procrustean standard. Such standards assume a homogeneity of population that does not exist, and Dr. Emmanuel presents counter-examples and outliers himself.

He further claims that a country that achieves life expectancy of 75 for both men and women need no longer concern itself with further life-lengthening efforts. This is a statistical fallacy. He does not state which life expectancy.

Our life expectancies change as we age. Much of the life expectancy quoted is at birth, including the risks of infant mortality. Life expectancy at age 18 is much different. Furthermore, life expectancy at age 70 is considerably higher, as there is a heightened risk of mortality in the fifties and sixties, with those reaching their seventies enjoying a much longer expectancy. On top of that, those are averages that say nothing about the experience of any one individual, and we live life as individuals not as averages, except for those rare individuals with precisely 2.4 children.

Second, when he points to the increase in disability and disease in extended old age, those figures apply to the general population, including the obese we see among us. They may not apply to those who climb Mt. Kilimanjaro in their fifties, as has Dr. Ezekiel.

Third, he is concerned about burdening his children, but he may prove to be a greater burden on his children by refusing available medical interventions than had he accepted them. A person with atrial fibrillation who has a pacemaker is less likely to experience a debilitating stroke than someone who refuses medical treatment. The only difference is that the stroke disability occurs in the person’s seventies rather than their eighties. That doesn’t sound the ethical high road to me.

Fourth, it is ironic that Dr. Ezekiel in pointing out the “spiritual and existential” reasons for his position to be rejected overlooks the religious drive behind his position: the desire for certainty in the face of life’s ambiguity. That drive motivates most religious belief in the same way that desiring to die at a fixed age “removes the fuzziness of trying to live as long as possible.”

Fifth, it could be that as a physician on record as opposing active euthanasia and recognizing that people do have disabilities that radically degrade their quality of life at an increasing rate with age; he is left with the only alternative being a form of very passive self-euthanasia, which he describes in other terms in the essay.

Now, the essay is replete with disclaimers that Dr. Ezekiel is not trying to convince us nor does he think it unethical to conclude otherwise and so forth. In short, he is restricting his conclusion to a population of one that we cannot know as well as he does. If that were truly so, the essay need not be published anywhere but a diary. So, I find the disclaimers to be disingenuous.

At the outset, I challenged Dr. Ezekiel’s wisdom but not his sincerity. I did so on two grounds.

First, in academic research, with which any physician is familiar, it is a cardinal rule to state what you know, what you don’t know, and what should be the next steps. My impression is that Dr. Ezekiel confuses what he knows with what he doesn’t know. Among the things he doesn’t know, not because he is not intelligent and knowledgeable, but because he is not omniscient are:

  1. What the outcomes of two personal time lines would be, one being the refusal of interventions and the other being the acceptance of interventions.
  2. What medical advances will occur in the next fifteen years to address some of his concerns about disability accompanying expanded life expectancy.

Have we not all wondered at some time, what if we had married person A instead of person B, what if we had taken job A rather than job B, visited country A rather than country B, and an almost infinite number of similar questions that are summarized in Robert Frost’s The Road Not Taken? And the power of the poem lies in our understanding that we simply cannot see the path that disappears in the underbrush, nor can Dr. Ezekiel.

In the field of economics, everyone becomes familiar with work of Thomas Malthus, who predicted widespread war and famine accompanying population growth. It may still happen, but it has not happened yet because Malthus was unable to take into account the impact of technological advance. The same technological advance that has helped us lengthen our lives by declining infant mortality and more hopeful outcomes to heart disease and cancer may yet address the disabilities accompanying aging. What I know is that at my age (67) I can walk 5 miles easily and 10 miles less easily whereas my parents’ generation could not at my age. I carry two stents in my heart, which have no lengthened my life but improved its quality such that I can climb a hill without feeling faint. Such qualitative improvements from technology should not be overlooked.

Second, the ancient Greeks had a word that survives in our studies of their literature and ours, hubris, an excessive pride or self-confidence. And, to me that is the lack of wisdom in an otherwise well-written, thoughtful essay. We have come a long way as a species. With luck and wisdom that we do not always demonstrate, we will have a long way to go. Part of that wisdom is a certain humility that I found lacking in the essay. Even about ourselves we know less than we pretend to know. A person contemplating his death at 75 does not know he will not be hit by a car at 60 or suffer a heart attack or learn he has pancreatic cancer. By the same token, there are imponderables on the other side of 75 as well, good and bad, desired and feared. A person cannot plan that way, but the humility of admitting those possibilities should come through in this essay.

Many years ago I lived in the backyard converted garage of an older couple in Miami, Florida. They had an old dog. One day, the man about 70 years old was musing about how the dog was arthritic, had trouble walking and could not climb up on his lap, and how perhaps it was time to put him down. It gives me pause and a needed dose of humility in thinking about such things to recall that the dog outlived the man.

Learning about fat people

When I was growing up, I had a first cousin who was morbidly obese, long before the efforts of the rest of the country to catch up with her. Her failure, and it was considered a failure, to lose weight was seen as evidence of a moral failing, a lack of willpower, only slightly less pejorative than the sin of gluttony in earlier times. There was some vague talk that she might have some hormonal imbalance, but it was clear that all around her considered her problem to be predominantly one of willpower.

Both alternative and scientific medicine have taken a recent interest in gastro-intestinal (GI) flora, or “gut bacteria.” The alternative medicine folks have favored “probiotic” supplements and yogurts fortified with bacteria. The probiotic movement began with Nobel laureate Elie Metchnikoff, known as the “father of probiotics,” who believed that longevity of rural Bulgarians and Georgians could be attributed to their consumption of fermented milk products.
Metchnikoff

Consideration of the impact of GI flora on diarrhea is not really new–a half century ago I can recall being given lacto-bacillus pills to counter the gastric distress resulting from penicillin. It is the potential impact of bacteria on obesity that is notable in the current focus. Recently National Public Radio (NPR) interviewed Jeffrey Gordon, a microbiologist and director of the Center of Genome Science and Systems Biology at the Washington University School of Medicine in St. Louis.

While I hope you will either listen to the embedded audio clip (about 12 minutes) or read the interview transcript, the short version is that there the research shows a recursive feedback loop between how the bacteria impact our appetite and how what we eat impacts the bacteria that are in our intestines. By eating the right or “lean” foods, we encourage the bacteria that help us maintain our weights at a healthy level. Now, there has been some experimentation with fecal transplants, having a similar aim, but that does not seem to be for everyone–particularly those of us who would be grossed out by the very idea. Eventually, we will probably have probiotics, which, combined with proper diet (they need to be fed or cultivated in our gut), can be delivered to our intestines in pill form, or at least a suppository rather than a fecal transplant.

Over time my cousin became estranged from nearly everyone in the family and died a few years ago, not having been seen by any family members in decades. Waxing philosophically, I cannot help but wonder how different my cousin’s life might have been had she been born a half-century or better a century later. And, I wonder how different my father’s life might have been had he survived his first heart attack and lived to see statin drugs.

It seems that much of our survival depends upon living just long enough for technology to address a mortal weakness in our genome. Nonetheless, it is encouraging to note that promising approaches to obesity may make it seem like nothing more interesting than a historical healthcare statistical blip rather than the crisis it appears to be as we live with it and address it.

Herd Immunity — How vaccines avoid thinning the herd

Part of the difficulty in making a case for universal vaccination against dangerous disease is a lack of understanding of probability. Since there are few certainties in life, except its eventual end for individuals, we are constantly calculating probabilities. What is the probability that I will get to the other side of the street before that oncoming car arrives? What is the probability that the wheel stop on my number or that I will draw the card needed to complete my hand? What is the probability that the game I am going to attend will occur or get rained out? And, of course, what is the probability that the suggested intervention will cure my disease rather than kill me or leave me permanently debilitated?

Some probabilities are more difficult to calculate than others: what are the odds that I will die from prostate cancer, and what are the odds that the operation will leave me impotent? how do I calculate the best course when my choices are an operation with an 80 percent success rate that leaves another 15 percent paraplegic and 5 percent dead? How about the same operation with 93 percent success, 5 percent paraplegic, and 2 percent dead?

The more complex the alternatives, particularly when they are being balanced against complex outcomes from non-intervention, the more difficult it is for us to make a rational decision.

That leads to a discussion of vaccination. Let’s consider a disease such as smallpox, which has killed 100s of millions of people. Not everyone got smallpox. Not everyone who got smallpox died from it–estimates are that about 30 percent, or 3 out of every 10 died. Now, consider that not everyone who gets a vaccination gets 100 percent immunity. Some people get partial immunity. Some very small percentage may not produce antibodies in reaction to the vaccine. Some people actually die of the side effects of the vaccination.

As an individual, you might think, well, it’s not great but 70 percent odds of surviving are better than none, and maybe it will miss me altogether, so why should I vaccinate? Of course, smallpox has been eradicated, and we don’t have to make that kind of determination any more since the dangers of side effects from the vaccination exceed the danger of contracting smallpox, particularly in the United States where the last documented case appeared in 1949.

If you were a free individual, not part of a society, not part of the possible transmission stream of a disease, then no one is likely to care too much what you decide? However, if you are reading this, you are part of a society providing this message to you via a societal mechanism. As part of that society, you have obligations to others in the society, including children, yours and others, who once were considered private property but are now considered individuals with rights, albeit limited compared to adult rights.

The concept of “herd immunity” goes directly to the questions posed and to your obligations within the society.

Herd Immunity Concept

Those who are vaccinated provide a barrier to illness for those who are not:

Consider:

Assume you have 5 friends who do not know one another, and that everyone has 5 such friends.

Assume that vaccinations give almost 100% immunity and that the corresponding disease gives almost 100% probability of infection if you come in contact with a person who has it.

Now, if 80 percent of people are immunized against the disease, it is quite possible that one of your friends is not immunized. However, if 80 percent of that person’s friends are immunized, there is now only 1/5 times 1/5 or 1/25 = 4 percent chance of the disease vector reaching you. It may be that you friend’s friend has friends with 100 percent immunity, all five of them immunized, and the further you are socially from the source of infection, the lower your odds of becoming infected–even if you are not immunized. You are protected by herd immunity.

However, consider if only 60 percent of people are immunized, then 2/5 times 2/5 is 4/25 or 16 percent chance of becoming infected. That is 4 times your chance of infection from a secondary friend, as in the first example. The degree of herd immunity is a complicated calculation depending upon the percent immunized and the way the disease is transmitted. Your chance of infection depends on those factors as well as your social distance from the source of the infection.

For an animated look at the concept, click on “Play Animation” in the three scenarios of The History of Vaccines: Herd Immunity.

Here are the thresholds for different diseases as estimated by the Centers for Disease Control (CDC):

Herd Immunity Thresholds CDC

Think about flu shots for a moment:

  1. The vaccine is based upon recent mutations of the virus, so you might catch a virus that is not part of the vaccine.
  2. Not everyone gets 100 percent protection from a vaccine–it may be sufficient to protect against some strains and give partial protection against others
  3. In part, because of herd immunity, not everyone exposed to influenza is infected

So, we have friends and relatives drawing the wrong conclusions (e.g. the vaccine caused me to get influenza), based on an association of factors that are coincidental or subject to an alternative explanation, such as a new strain or partial immunity. For most young people, the flu is an occasional inconvenience rather than life-threatening; however, their failure to vaccinate exposes others whom they could be protecting by a simple annual injection. Let’s spread the word–it might not save those young individuals–just an older person, or an asthmatic standing close to them.

How Do We Implement What Works?

Medicare is abandoning the one experimental program that works. So claims Ezra Klein of the Washington Post in “If this was a pill, you’d do anything to get it.”

Klein describes a program by Healthy Quality Partners (HQP) where nurses make home visits to geriatric patients with chronic illnesses. It has been subsidized by Medicare as an experiment, in which some randomly chosen patients receive the intervention while some do not. The results have been better outcomes at lower cost to Medicare per the article as well as a study published last July.

Let’s assume that the claims are true: better outcomes and lower costs. How do we take an experiment, and by definition experiments have a beginning and an end, and generalize it into practice?

There are numerous possibilities:

First, we could do what the article implies: provide more government funds to Healthy Quality Partners, instructing them to expand the experiment operationally beyond the 1,736 members in Pennsylvania. I am assuming that maintaining indefinitely a small-scale experiment that works makes no sense–onward and upward.

Second, we could change the reimbursement scheme at Medicare to provide reimbursement for such services so that anyone in the country could create a similar program with the financial incentive of knowing that Medicare would reimburse the services.

Here is how that second possibility has developed:

The Clinical Procedure Terminology (CPT) codes were created and are owned by the American Medical Association. Recently Medicare adopted additional CPTs for coding reimbursement for coordination of care services.

Care Coordination CPTs

A statement by the American Nurses Association (ANA) is enthusiastic about the addition of the codes. Note: the ANA participates on the AMA CPT and RVU Update Committee.

ANA Care Coordination

Eileen Shannon Carlson RN, JD of the ANA points out that it is rare for CPTs to be adopted that only apply to nurses, as do two of chronic care coordination additions.

To be fair, the new codes only reimburse care coordination after a hospitalization and for a short period of time, why the HQP initiative addressed the needs of the elderly with chronic conditions. Nonetheless, I can imagine the next step being a protocol to target care coordination for the elderly independent of a hospitalization. Contrary to much in the popular press, government programs are very aware of spending dollars and getting value in return, so they limit risk by taking baby steps in developing programs.

Ezra Klein may well be correct, or he might be underestimating the challenge of turning a large ship, particularly when the upfront costs of such a turn may be prohibitive. What do you think?

Bad News for Boomers: Our Parents Were Healthier

As Americans we believe in progress, in a better tomorrow, sometimes with a bump in the road or a hiccough, but always a better tomorrow.

The data are in (March 4,2013 edition of JAMA Internal Medicine), and it ain’t happening for boomers. Blood pressure, cholesterol, diabetes, and obesity–all greater than the previous generation.

Boomer_Parent_Comparison_JAMAinternalmed_20130304
Source: The Status of Baby Boomers’ Health in the United States The Healthiest Generation?
Dana E. King, MD, MS; Eric Matheson, MD, MS; Svetlana Chirina, MPH; Anoop Shankar, MD, PhD, MPH; Jordan Broman-Fulks
JAMA Intern Med. 2013;173(5):385-386

Although longevity has risen during the twenty-year gap between the two groups, every other indicator of health, except smoking, has become less favorable. And the pattern is clear.

At the top of the following chart are general measures of health. Then, we can see that lifestyle factors have declined leading to the trends in the last section: declining indicators of cardiovascular health.

We can’t choose to be healthy or not: what we can do is make healthy choices by changing the lifestyle factors.

We are choosing illness at great expense to ourselves, both financially and in quality of life, while continuing to endure longer and sicker lives instead of enjoying healthier lives.

Boomer_Parent_Extract_Comparison

Fat old people have a problem. Fat old people are a problem.

Bette Davis famously said, “Old age is no place for sissies.” Growing old is challenge enough, so is being obese—but put them together and . . . .

Among the challenges:

1. Accelerated cognitive decline. A recent study found that cognitive decline was accelerated among the obese with any two of the four abnormalities:
a. High triglycerides or use of lipid-lowering medications
b. High low-density lipoproteins (LDL)
c. Elevated blood pressure or use of blood pressure medications
d. Elevated blood glucose

A 2009 Nursing World article added the following life-threatening illnesses:

2. Cardiovascular Disease. Over 80 percent of older Americans dies from this disease. Obesity seems to exacerbate the inflammatory process that underlies it.

3. Gallbladder Disease. Obesity is believed to effect a decrease in bile salts and increase in cholesterol.

4. Cancer. The evidence that obesity is a risk factor for cancer, particularly breast cancer, is growing.

5. Diabetes. Even relatively small weight gains can provoke a genetic tendency toward diabetes, so much the worse for the large weight gains that result in obesity.

As well as the nonfatal ailments:

6. Respiratory Problems. Lungs decrease in size, and the chest wall becomes heavier.

7. Arthritis and Osteo-arthritis. While arthritis is a general challenge for older adults, obesity puts weight on the knee and hip joints, resulting in damage to cartilage.

8. Skin conditions. Perspiration and friction can lead to persistent skin conditions.

The necessary emotional and financial burden of caring for the aged in our society, as well we should, is inflated by the unnecessary burdens of avoidable disease and disability. As we address the health needs of our population, we must lessen the burden of the aged on our society, not by decreasing available benefits but by decreasing needs. That goal requires improving health before and during old age.

Further reading:
Obesity Among Older Americans
National Blueprint: Increasing Physical Activity Among Adults Age 50 and Over
Effect of Obesity on Falls, Injury, and Disability